There's a book I read over a decade ago that changed the way I think about pain — and more importantly, the way I talk to my patients (and the world) about it.
It's called Explain Pain, written by David S. Butler and G. Lorimer Moseley. It remains one of the most important resources in the field of pain science. It's also one of the most accessible — written for patients, not just clinicians. I've recommended it more times than I can count in my chiropractic practice, and I reach for it most often when someone is stuck: not getting better the way they should, avoiding movement, or convinced their body is broken in a way that can't be fixed.
This post is my attempt to explain why it matters — and why I think it's worth your time.
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The Core Idea: Pain Is Not What You Think
Most people understand pain the same way. Something gets hurt or damaged, a signal travels from that spot to the brain, and you feel pain. The more damage, the more pain. Heal the tissue, remove the source, and the pain goes away.
This model feels intuitive. It's also largely incorrect — and understanding why it's wrong is the first step toward getting better.
Explain Pain opens with this premise and doesn't let go: pain is not a signal that travels from tissues to your brain. Pain is an output — produced by the brain — in response to what the brain perceives as a threat.
This is not a philosophical point. It is a neurobiological one, and the distinction matters enormously for anyone dealing with pain that won't resolve on the expected timeline.
Danger Messages, Not Pain Messages
Here's where it gets specific in a way that's worth sitting with.
Your body is covered in sensors called nociceptors. These sensors respond to stimuli that are potentially threatening — extreme heat, compression, chemical changes from inflammation, mechanical stress. When activated, they send a signal up through the spinal cord toward the brain.
Here is the critical part: those signals do not say "pain." They say "danger."
The brain receives that information, integrates it with everything else it knows — your memories, your beliefs about what's happening, your stress level, what you're in the middle of doing, the social context you're in — and then makes a decision. Is this a credible threat? Does this body need to be protected?
If the brain answers yes, it produces pain. Pain is the alarm. It's the brain's way of getting you to stop, attend, and protect. As the book puts it: pain is always a normal response to what the brain thinks is a threat.
The consequence of this model is not abstract. It means:
- You can have pain without significant tissue damage (the danger alarm can be activated by memory, fear, stress, or expectation)
- You can have tissue damage without pain (the brain can suppress alarm signals when action is needed — soldiers in battle, athletes in competition, saving a loved one in a dangerous situation)
- Pain can persist long after tissues have healed if the alarm system has become overactive
This last point is especially important for anyone dealing with persistent or chronic pain. It is not a sign of ongoing damage. It is a sign that the brain's alarm system has been recalibrated — and the good news is that calibration can be changed.
→ Read Explain Pain on Amazon
→ Listen on Spotify
The Pain Web: It Was Never Just Physical
One of the most powerful concepts the book introduces is what researchers have called the pain web — the full set of systems and inputs that contribute to any pain experience.
The brain does not produce pain based on tissue signals alone. Every pain experience is built from:
- Sensory input — what nociceptors are reporting from the body
- The motor system — how the body is moving or guarding
- The sympathetic nervous system — stress, arousal, threat response
- The immune system — inflammation, healing activity, system-wide sensitization
- The endocrine system — hormones, cortisol, systemic stress responses
- Cognitive factors — beliefs, expectations, previous pain experiences, "thought viruses"
- Social and emotional context — whether you feel safe, supported, heard
What this means is that pain is always a whole-person experience. A person's fear of re-injury, their belief that their back is "structurally ruined," the sleep deprivation they've been living with, the job stress they're carrying — all of these are legitimate inputs to the pain system. They don't make pain less real. They make it more complex, and they point toward a fuller set of levers for changing it.
This is something I think about constantly in practice. When a patient comes in and tells me their pain is an 8 out of 10 but their imaging is relatively benign, or when someone's symptoms don't follow the anatomical pattern I'd expect — the pain web is usually where the answer lives. It's not that their pain is "in their head." It's that their pain is being amplified by systems we haven't addressed yet.
The research behind this model has been formalized in pain neuroscience literature, notably by Moseley and Butler in their review of the evidence for pain neuroscience education [Moseley GL, Butler DS. Fifteen Years of Explaining Pain: The Past, Present, and Future. J Pain. 2015;16(9):807–813] — confirming that education about how pain works is itself a therapeutic intervention, not just background information.
"Thought Viruses" and Why Your Brain's Beliefs Matter
Butler and Moseley dedicate significant attention to what they call "thought viruses" — deeply held beliefs about pain and the body that are both widespread and actively harmful. Things like:
"Pain means damage." "If it hurts, I should rest." "My scan showed a bulging disc — that's why I'm in pain." "I'll just have to live with this."
These beliefs aren't just unhelpful psychologically, they are active inputs to the pain system. Fear and avoidance of movement maintain the brain's threat assessment, keep the alarm elevated, and prevent the nervous system from recalibrating. The book makes the case — backed by the research — that reconceptualizing pain isn't a soft intervention. It is a neurobiological one.
I see the impact of these thought viruses almost every day in practice. Someone comes in having been told their disc is "crumbling" or their spine is "out of alignment," and that story has become a lens through which they interpret every twinge. Part of what I do — and part of what this book equips patients to do themselves — is replace that story with one that's more accurate, and more hopeful. That shift in understanding is often where recovery and empowerment actually begins.
Patients who understand how pain works move more, fear less, and recover differently. The research supports this consistently.
Why I Recommend This Book to My Patients
As a chiropractor, I work with people across a wide range of pain presentations — necks, backs, shoulders, hands and wrists, persistent post-injury sensitivity. And pain science education is part of how I work with almost all of them.
What I've learned over years of practice — and what this book helped me articulate — is that the people who struggle most are those operating under the tissue-damage model. They're waiting for the scan to "explain" their pain. They're avoiding movement because movement hurts. They've stopped trusting their body. They're stuck in a loop that passive care alone doesn't break.
Explain Pain is a tool for breaking that loop. Not because it gives people a way to ignore pain, but because it gives them an accurate framework for understanding it — and accurate frameworks lead to better decisions about movement, load, recovery, and care. I hand it to patients. I work through it with them in sessions. And I've watched it shift outcomes in ways that treatment alone often doesn't.
→ Listen to Explain Pain on Spotify
Take the First Step
If you're ready to move from understanding pain to actively changing it, a 15-minute consult is the place to start. We'll look at what's going on, whether a structured loading program makes sense for your situation, and what the path forward looks like. We’re based out of Calgary but feel free to book a virtual consultation if you want to discuss your situation.
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Learn more about Hand & Wrist Foundations →
By the way, if you're dealing with hand or wrist pain that hasn't responded the way you expected — whether that's carpal tunnel symptoms, tennis elbow, wrist tendonitis, or persistent post-injury sensitivity — this book is a useful starting point for understanding what's actually happening.
And if you want to work on the physical side — progressive loading, tissue conditioning, grip and wrist strength — that's exactly what Hand & Wrist Foundations is built for.
Reference
Moseley GL, Butler DS. Fifteen years of explaining pain: the past, present, and future. J Pain. 2015;16(9):807–813.
Butler DS, Moseley GL. Explain Pain. Adelaide: Noigroup Publications; 2003.
More About The Author
Amy MacKinnon, Co-Founder of Vital Performance Care
Dr. Amy MacKinnon is the co-owner of Vital Performance Care, Coven Health Collective, and Coalition Health Group. A former varsity soccer athlete turned chiropractor, she works with athletes and individuals across all levels, from grassroots to Olympic and professional sport.
Amy has served as Performance Director for multiple sport organizations and worked internationally with Bobsleigh Canada Skeleton, including at the 2018 PyeongChang Olympic Winter Games. Her work is grounded in community, connection, and bridging therapy and performance to help people move and live better.